As he asked around about organisms, beyond flies, worms, and mice, that might help us understand the biology of aging, a whole menagerie has come out of the woodwork. He heard about bats that can survive a storm of human-killing pathogens and naked mole-rats that live decades longer than their fur-covered cousins.
He heard about clams that gurgle on the seafloor for years; you can read the passage of time in the lines on their shells, as if they were rings on a tree. Eventually, he also heard about rotifers. They were different from those bats, rats, and quahogs: What attracted researchers like Gribble was not how long rotifers lived but how quickly they died.
The risk is remote with rotifers: When not in desiccation survival mode, their life cycle lasts only a few weeks. Biologists the world over still work on them. That means their life histories have been pored over, their reproductive habits prodded. Gribble uses that to her advantage. But if she wants to introduce variation in their genes, she can tweak their environment, nudging them toward making males and having sex.
Instead, her team videotapes and measures how they twitch and flick and swim.
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That inclination, it turns out, wanes with age. Using those kinds of behavior, Gribble and many others have started to untangle the wires that might be driving such late-life changes. That under certain conditions, reducing the calories of their algal diets might extend their lives. No matter how many genes a creature might share with us, the usual caveats of animal research apply.
Before they might come anywhere close to helping humans, whatever observations occur among the rotifers will have to move up the evolutionary tree, into other invertebrates and then rodents and then larger mammals. About five years ago, Karl Rodriguez, of the University of Texas Health Science Center at San Antonio, got to talking with her at an aging conference held on a dude ranch. He was a naked mole-rat and C.
He wanted to know more, so she shipped him some. They arrived by the thousands, frozen in vials, kept cold by Styrofoam.
Then he started measuring the levels of different molecules. The force needed to break through it also tore apart the compounds he was trying to study. By Sharon Begley. By Rebecca Robbins. By Shraddha Chakradhar. Leave a Comment Cancel reply Name Please enter your name. Email Address Please enter a valid email address.
Comment Please enter a comment. Notify me of followup comments via e-mail. Scientists are placing their bets. Topics that will be covered will include senescence, immune system aging, cognitive decline with aging, clinical and genomic biomarkers of aging. In addition, there will be talks on recent advances in genomic technologies such as single cell profiling technologies and microbiome profiling.
Handbook of the Biology of Aging - 7th Edition
There will a poster session for trainees and other attendees on September 4th. You are invited to submit an abstract while registering to be considered for a poster presentation. Please contact the event organizer for more information. Sep 04 - Aging is a complex and multi-dimensional phenotype that affects all tissues of all organisms. In humans, aging—related diseases, including cardiovascular diseases, cancer and type 2 diabetes, pose a huge health and economic burden, which will continue to increase as the aging population is expected to double by Disruption of immune cell functions and responses plays a significant role in the etiology of many aging-related diseases.
Recent advances in genomic technologies e. However, uncovering the functional and clinical significance of these genomic and cellular changes is a significant computational challenge. Participants are responsible for their own lodging accommodations. Homewood Suites by Hilton Hartford Farmington.
Includes a free shuttle service to The Jackson Laboratory.
What causes human bodies to age? Here’s what scientists know about the biology behind growing old
Farmington Inn. Hartford Marriot — Farmington. Participants are responsible for their own travel arrangements.
Car rental, public transportation, and taxi services are available from Bradley International Airport. What is Personalized Medicine? Genetics vs. Why Mice? You are invited to submit an abstract while registering to be considered for a poster presentation Registration is Full Please contact the event organizer for more information. Sep 04 - 05 Jump to. About Aging is a complex and multi-dimensional phenotype that affects all tissues of all organisms. Download full Schedule. September Laura Haynes, Ph. Catherine Cook Kaczorowski, Ph. Jorg Goronzy, M.
Derya Unutmaz, M. Ruth Montgomery, Ph. Bram Gerritsen, Ph.
Postdoctoral Associate Yale University. Jacques Banchereau, Ph. Karen Conneely, Ph. Kathryn Miller-Jensen, Ph.
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